Targeting the innate repair receptor to treat neuropathy
نویسندگان
چکیده
منابع مشابه
Targeting the innate repair receptor to treat neuropathy
The innate repair receptor (IRR) is a heteromer of the erythropoietin receptor and the β-common (CD131) receptor, which simultaneously activates anti-inflammatory and tissue repair pathways. Experimental data suggest that after peripheral nerve injury, the IRR is upregulated in the spinal cord and modulates the neurogenic inflammatory response. The recently introduced selective IRR agonist ARA2...
متن کاملComplexities of targeting innate immunity to treat infection.
Innate immunity is an ancient form of host defence that is activated rapidly to enable, through a multiplicity of effector mechanisms, defence against a broad spectrum of microbial threats. From this perspective, innate immunity has desirable characteristics of a therapy against infections, and, as a consequence, the innate immune system has become a major target for the development of therapeu...
متن کاملTraumatic optic neuropathy--to treat or not to treat?
CASE REPORTS We present two cases of blunt ocular trauma with clinical findings and complementary tests compatible with traumatic optic neuropathy (TON), and progression to sectorial optic atrophy. DISCUSSION TON have an essentially clinical diagnosis, and in the last few years has been treated with high doses of intravenous steroids, based on weak evidence of the benefit of the steroids in c...
متن کاملTargeting Interferon- to Treat Atherosclerosis
The chronic inflammatory nature of atherosclerotic disease is now widely appreciated. Abnormal deposition and oxidative modification of serum lipoproteins in arterial walls stimulates the recruitment of monocytes and their conversion into foam cells. Concurrently, both innate and adaptive immune responses are induced. Cytokines and growth factors produced as part of these responses lead to the ...
متن کاملTargeting the tumor niche to treat cancer.
Sattva S. Neelapu and Padmanee Sharma Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; and Department of Immunology...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PAIN Reports
سال: 2016
ISSN: 2471-2531
DOI: 10.1097/pr9.0000000000000566